A child with hemophilia A will have which abnormal laboratory result?
a. PT (ProTime)
b. Platelet count
c. Fibrinogen level
d. PTT (partial thromboplastin time)
ANS: D
The basic defect of hemophilia A is a deficiency of factor VIII. The partial thromboplastin time measures abnormalities in the intrinsic pathway (abnormalities in factors I, II, V, VIII, IX, X, XII, HMK, and KAL). The prothrombin time measures abnormalities of the extrinsic pathway (abnormalities in factors I, II, V, VII, and X). Fibrinogen level is not dependent on the intrinsic pathway. Platelets are not affected with hemophilia A.
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