What is the mechanism of action of sumatriptan (Imitrex) and other triptans?
1. They cause vasoconstriction of cranial arteries.
2. They block prostaglandin synthesis.
3. They block COX-2.
4. They affect mu receptors.
Correct Answer: 1
Rationale 1: Triptans cause vasoconstriction of cranial arteries.
Rationale 2: They block prostaglandin synthesis is incorrect because triptans cause vasoconstriction of cranial arteries.
Rationale 3: They block COX-2 is incorrect because triptans cause vasoconstriction of cranial arteries.
Rationale 4: They affect mu receptors is incorrect because triptans cause vasoconstriction of cranial arteries.
Global Rationale: Triptans cause vasoconstriction of cranial arteries. They block prostaglandin synthesis is incorrect because triptans cause vasoconstriction of cranial arteries. They block COX-2 is incorrect because triptans cause vasoconstriction of cranial arteries. They affect mu receptors is incorrect because triptans cause vasoconstriction of cranial arteries.
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