A 9-month-old was diagnosed with osteogenesis imperfecta (OI). This disease is caused by:
a. uterine teratogens.
b. a genetic defect.
c. malnutrition.
d. trauma.
ANS: B
OI (brittle bone disease) is a spectrum of disease caused by genetic mutation in the gene that en-codes for type I collagen, the main component of bone and blood vessels.
OI (brittle bone disease) is not due to teratogens, malnutrition, or a fracture.
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