Atorvastatin (Lipitor) is a statin that can be used to lower blood cholesterol levels by
1. binding exogenous cholesterol and excreting it in the feces.
2. increasing excretion by activating enzymes within the hepatic system.
3. preventing dietary absorption within the GI tract.
4. inhibiting an enzyme that is essential for cholesterol synthesis.
Correct Answer: 4
Rationale: Statins work by inhibiting the enzyme HMG-CoA reductase. HMG-CoA reductase is essential for cholesterol biosynthesis. Bile acid resins bind cholesterol and promote its excretion in the feces.
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