What is the mechanism of action of memantine (Namenda)?
a. Increases production of dopamine
b. Decreases production of serotonin
c. Blocks N-methyl-D-aspartate (NMDA) receptors in the central nervous system (CNS)
d. Enhances reuptake of central neurotransmitters
ANS: C
Although the causes are unknown, one of the neurochemical characteristics of Alzheimer's disease is persistent activation of NMDA receptors in the CNS. Memantine blocks these receptors and is used alone or in combination with an acetylcholinesterase inhibitor in the treatment of moderate to severe Alzheimer's dementia. A diet high in tyrosine, a precursor of dopamine, might increase production of the neurotransmitter. Serotonin production is largely influenced by exercise; increasing exercise stimulates the production of more neurotransmitters. Reuptake of central neurotransmitters, a natural event, may be enhanced by drugs such as selective serotonin reuptake inhibitors.
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