The nurse is researching a drug recently released on the market to determine what the median lethal dose (LD50) was in preclinical trials. The nurse recognizes that this number reflects which fact?
1. The dose at which 50% of the research animals died
2. A measurement of the potency of the drug
3. The value of relative safety of the drug
4. The dose that produced signs of toxicity in 50% of lab animals
Correct Answer: 1
Rationale 1: The dose at which 50% of animals in the preclinical trials are killed is the median LD50 dose.
Rationale 2: A comparison of two drugs is done when defining the potency of a drug.
Rationale 3: Relative safety of dose is reflected in the therapeutic index.
Rationale 4: The dose at which signs of toxicity are seen in 50% of laboratory subjects is the median toxicity dose.
Global Rationale: The dose at which 50% of animals in the preclinical trials are killed is the median LD50 dose. A comparison of two drugs is done when defining the potency of a drug. Relative safety of dose is reflected in the therapeutic index. The dose at which signs of toxicity are seen in 50% of laboratory subjects is the median toxicity dose.
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The teaching plan for a woman who wishes to use the female condom should include that it:
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