Which description is consistent with acute lymphocytic leukemia (ALL)?
a. ALL is a progressive neoplasm defined by the presence of greater than 30% lymphoblasts in the bone marrow or blood.
b. Leukocytosis and a predominance of blast cells characterize the bone marrow and peripheral blood. As the immature blasts increase, they replace normal myelocytic cells, megakaryocytes, and erythrocytes.
c. B cells fail to mature into plasma cells that synthesize immunoglobulins.
d. The translocation of genetic material from genes 9 and 22 create an abnormal, fused gene identified as BCR-ABL.
Answer: a. ALL is a progressive neoplasm defined by the presence of greater than 30% lymphoblasts in the bone marrow or blood.
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