A 62-year-old female with a diagnosis of acute and chronic renal failure secondary to diabetes mellitus is receiving her weekly injection of epoetin, a supplementary form of erythropoietin
Which of the following statements best captures the necessity of this medication?
A)
Erythropoietin is needed in order for stem cells to proliferate into committed erythroid precursors.
B)
Erythropoietin is necessary for the accurate sensation of hypoxia that stimulates erythropoiesis.
C)
Erythropoietin causes the erythrocyte colony-forming units to proliferate and mature.
D)
Erythropoietin facilitates the extrusion of the reticulocyte nucleus and the formation of true erythrocytes.
Ans:
C
Feedback:
Erythropoietin acts primarily in later stages of erythropoiesis to induce the erythrocyte colony-forming units to proliferate and mature through the normoblast stage into reticulocytes and mature erythrocytes. It does not act directly on the stem cells, nor does it play a role in the sensation of hypoxia. Reticulocytes already lack a cell nucleus.
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