Which of the following cells will likely stay in a permanent resting state known as G0, unless there is a change in nutrients, growth factors, or hormones that trigger cell renewal?
A) Stratified squamous epithelium of the skin
B) Cells lining the esophagus and intestines
C) Neurons
D) Cancerous cells
Ans: C
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When environmental conditions are adverse, such as nutrient or growth factor unavailability, or cells become terminally differentiated (i.e., highly specialized), cells may exit the cell cycle, becoming mitotically quiescent and reside in a special resting state known as G0. Cells in G0 may reenter the cell cycle in response to extracellular nutrients, growth factors, hormones, and other signals such as blood loss or tissue injury that trigger cell renewal. Highly specialized and terminally differentiated cells, such as neurons, may permanently stay in G0. The skin, cells lining the GI tract, and cancer cells are continuously dividing and going through the cell cycle.
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