The mechanism(s) underlying the development of cardiac hypertrophy is(are) complex, though relaxation abnormalities resulting in a chronic elevation of cytosolic Ca++ level appear to promote the development of hypertrophy through:
A. stimulation of the sarcolemmal Ca++ pump
B. Ca++ binding to troponin I
C. activation of calcineurin
D. inhibition of Ca++-calmodulin-dependent protein kinase
E. opening Ca++-activated K+ channels
ANS: C
Anatomy & Physiology
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