Which of the following statements is true about susceptibility testing or treatment of P. aeruginosa?
a. Susceptibility testing is required to detect intrinsic resistance.
b. Repeat susceptibility testing may be needed to monitor development of resis-tance.
c. Susceptibility testing of isolates from cys-tic fibrosis patients following standard protocols gives reliable results.
d. Treatment with a single antimicrobial agent, such as <-lactam with antipseu-domonal activity, is recommended.
B
P. aeruginosa may develop resistance during therapy with any antimicrobial agent within 3 to 4 days; thus, repeat susceptibility testing may be required to monitor development of resistance. Susceptibility testing is done to detect acquired resistance; intrinsic resistant is predictable (i.e., known). Therapy usually involves the use of more than one agent; for example, a ?6ß-lactam developed for antipseudomonal activity and an aminoglycoside are frequently prescribed. The particular therapy used depends on several clinical factors and on the laboratory antimicrobial resistance profile for the P. aeruginosa isolate. Standard incubation time for AST of P. aerugi-nosa isolates is 16 to 20 hours; however, slower-growing, more mucoid P. aeruginosa isolated from CF patients may require extended incubation for up to 24 hours before obtaining a reliable susceptibility pattern.
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Indicate whether the statement is true or false
Which of the following is a FALSE statement about prokaryotes?
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