Which drug class has been found to decrease mortality if given within 8 hours of a MI due to a decrease in cardiac workload?
1. Antiplatelet
2. Beta-adrenergic blockers
3. ACE inhibitors
4. Calcium channel blockers
Correct Answer: 2
Rationale 1: Antiplatelet is incorrect. Beta blockers have been found to reduce mortality if given within 8 hours of the MI.
Rationale 2: Beta blockers are used for MI, as they are for angina, to reduce the cardiac workload. Beta blockers have the ability to slow the heart rate, decrease contractility, and reduce blood pressure. These three actions reduce the cardiac oxygen demand, which is beneficial for those who experienced a recent MI. In addition, their ability to slow impulse conduction through the heart tends to suppress dysrhythmias, which can be serious and sometimes fatal complications following MI. Their use has been found to reduce mortality following an MI if given within 8 hours of the MI.
Rationale 3: ACE inhibitors is incorrect. Beta blockers have been found to reduce mortality if given within 8 hours of the MI.
Rationale 4: Calcium channel blockers is incorrect. Beta blockers have been found to reduce mortality if given within 8 hours of the MI.
Global Rationale: Beta blockers are used for MI, as they are for angina, to reduce the cardiac workload. Beta blockers have the ability to slow the heart rate, decrease contractility, and reduce blood pressure. These three actions reduce the cardiac oxygen demand, which is beneficial for those who experienced a recent MI. In addition, their ability to slow impulse conduction through the heart tends to suppress dysrhythmias, which can be serious and sometimes fatal complications following MI. Their use has been found to reduce mortality following an MI if given within 8 hours of the MI. Antiplatelet is incorrect. Beta blockers have been found to reduce mortality if given within 8 hours of the MI. ACE inhibitors is incorrect. Beta blockers have been found to reduce mortality if given within 8 hours of the MI. Calcium channel blockers is incorrect. Beta blockers have been found to reduce mortality if given within 8 hours of the MI.
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