R.T.'s surgical course is uneventful and he is discharged after 5 days. Based on the final pathology report,
his cancer is designated stage IIIB. The cancer had spread to the muscle layer of the colon wall with nine
lymph nodes being positive.
Four weeks after surgery, R.T. is scheduled to begin 6 months of adjuvant
chemotherapy.
Describe three chemotherapy regimens used to treat stage IIIB colon cancer. Underline the
two drugs common to all three regimens.
• FOLFOX4: 5-fluorouracil (5-FU), oxaliplatin (Eloxatin), and leucovorin (folinic acid)
• Levamisole regimen: 5-FU and leucovorin (folinic acid)
• Mayo Clinic/North Central Cancer Treatment Group (NCCTG) regimen: 5-FU and low-dose
leucovorin (folinic acid)
• Roswell Park or National Surgical Adjuvant Breast and Bowel Project (NSABP) regimen: 5-FU and
high-dose leucovorin (folinic acid)
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