What are the abnormal cytoplasmic inclusions in Chédiak-Higashi?
a. Nuclear fragments that prevent cell division
b. Ribosomal material that looks like Döhle bodies
c. Fused granules that inhibit bactericidal functions
d. Mucopolysaccharide lipids that disrupt cell function
ANS: C
Abnormally large fused granules that are peroxidase positive are seen in Chédiak-Higashi syndrome. Uncontrolled activity of the granular membrane creates large primary, secondary, and mixed primary/secondary granules. These inhibit the normal bactericidal function of these granules so that patients are susceptible to bacterial infection.
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