Describe how exon shuffling could lead to the formation of novel proteins
What will be an ideal response?
Exon-intron junctions often fall at points that divide major functional regions, or domains, in encoded
proteins. Genetic duplications and rearrangements can occasionally cut and paste parts of different
genes together. When the cutting and pasting happens within introns, this will bring together novel
combinations of exons that will produce a new protein. The individual domains generally retain their
specific functionality in the new protein. This mechanism can produce changes more quickly and more
efficiently than random point mutations that only affect individual amino acids in a protein.
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