An adolescent is receiving methotrexate chemotherapy after undergoing limb-salvage surgery for osteogenic sarcoma. Which statement by the adolescent indicates understanding of the purpose of leucovorin therapy after the methotrexate?
1. "I'm glad I only need one dose of the leucovorin."
2. "I don't have any pain so I won't need to take the leucovorin this time."
3. "I know I will be taking the leucovorin every 6 hours for about the next 3 days."
4. "I don't have any nausea so I won't need the leucovorin."
Correct Answer: 3
Rationale: Leucovorin (citrovorum factor) is a form of folic acid that helps to protect normal cells from the destructive action of methotrexate. It is started within 24 hours of methotrexate administration and is given along with hydration therapy. Usual administration is every 6 hours for 72 hours or until serum methotrexate is at the desired level.
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