A client who has developed a resistance to levofloxacin (Levaquin) is concerned that getting rid of the infection will be impossible. What is the best response by the nurse to the client?
1. "The physician will admit you to the hospital and put you on an IV form of levofloxacin (Levaquin). You will not be resistant to that."
2. "The physician will take you off of the levofloxacin (Levaquin) for a few days and then have you start taking it again. Then it will be effective."
3. "The physician will switch you from levofloxacin (Levaquin) to ciprofloxacin (Cipro)."
4. "The physician will switch you to another type of antibacterial to which you haven't developed resistance."
Correct Answer: 4
Rationale 1: Placing the client on IV administration will not change the resistance.
Rationale 2: A drug holiday will not change the resistance factor. It is also unsafe not to treat this client's infection.
Rationale 3: It would not be effective to switch a client from one fluoroquinolone to another fluoroquinolone, because resistance to one usually confers resistance to the others in the same class.
Rationale 4: The physician will switch the client to another class of antibacterial to which the client has not developed resistance.
Global Rationale: The physician will switch the client to another class of antibacterial to which the client has not developed resistance. Placing the client on IV administration will not change the resistance. A drug holiday will not change the resistance factor. It is also unsafe not to treat this client's infection. It would not be effective to switch a client from one fluoroquinolone to another fluoroquinolone, because resistance to one usually confers resistance to the others in the same class.
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