When administering aspirin to a patient with a history of peptic ulcer disease, the nurse may anticipate administering which drug(s) for prophylaxis against aspirin-induced ulcers? (Select all that apply.)
a. Misoprostol (Cytotec)
b. Ranitidine (Zantac)
c. Omeprazole (Prilosec)
d. Lansoprazole (Prevacid)
e. Antacids
ANS: A, C, D
Misoprostol stimulates prostaglandin synthesis and is used for prophylaxis in patients taking aspirin. Omeprazole and lansoprazole are proton pump inhibitors that can be used to prevent and treat aspirin-induced ulcers, because proton pump inhibitors suppress gastric acid.
Ranitidine and antacids are not indicated for the prevention and treatment of aspirin-induced ulcers.
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