The client who has been taking the oral antidiabetic agent pioglitazone (Actos) for 6 months reports to the nurse that his urine is darker than it used to be. What is the nurse's best action?

A. Notify the physician.
B. Document the report as the only action.
C. Instruct the client to increase his water intake.
D. Test a sample of urine for the presence of occult blood.


A
The "glitazone" drugs, including pioglitazone, have been reported to affect liver function, and there have been some cases of liver failure. Dark urine is one indicator of liver impairment be-cause bilirubin increases in the blood and is excreted in the urine.

Nursing

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