A congenital deficiency of transferrin results in:
a. Severe anemia
b. Reduced absorption of iron
c. Increased excretion of iron
d. Decreased storage of iron in organs
ANS: A
Transferrin is the carrier protein for iron. If it is deficient, then iron cannot be effectively transported to developing RBCs (or storage), and a severe iron deficient anemia develops. When transferrin is deficient or absent, iron is absorbed through the intestine and stored in the liver, pancreas, and spleen, but very little gets to the bone marrow.
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