Thyroid hormone secretion decreases with age. Treatment with thyroid-releasing hormone is less effective in younger patients, while treatment with thyroid hormone is more effective in younger patients. What name is given to the condition of decreased thyroid hormone secretion? What related hormones are likely to decrease as well? Propose an explanation for the loss of responsiveness to the
releasing hormone. Propose an explanation for the increased responsiveness to treatment with thyroid hormone (consider both how hormones affect target cells and how hormone action is halted).
What will be an ideal response?
The condition is hypothyroidism. Thyroid-stimulating hormone and thyroid-releasing hormone likely also decrease. Decreased responsiveness to injected releasing hormone may indicate a loss of hormone receptors in the anterior pituitary. Increased responsiveness to injected thyroid hormone may indicate up-regulation of hormone receptors in the target tissues, or it may indicate decreased metabolism of the circulating hormone.
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