A client with advanced cancer is being treated with intravenous mithramycin (Mithracin). Which clinical manifestation indicates that the treatment is effective?
a. Bowel sounds are active in all four qua-drants.
b. The client's serum sodium level is 138 mEq/L.
c. The pulse rate is 68 beats/min and bound-ing.
d. Urine output has increased to 30 mL/hr.
A
Mithramycin is used to treat hypercalcemia, which is seen most often in oncology clients who have bone metastases. Hypercalcemia reduces excitable membrane activity, causing decreased intestinal motility. Return of intestinal motility is an indication that serum calcium levels are de-creasing. Mithramycin has no direct effect on serum sodium levels or urine output. The pulse rate most likely would be rapid and irregular with hypercalcemia and would normalize as calcium levels return to normal.
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