The nurse on an oncology unit is planning care for clients with various types of cancer. The nurse recognizes that certain cancer cells have a low growth fraction and are less sensitive to chemotherapeutic agents, including:
Standard Text: Select all that apply.
1. leukemia cells.
2. lymphoma cells.
3. breast cancer cells.
4. lung cancer cells.
5. bone marrow cells.
Correct Answer: 3,4
Rationale 1: Leukemia cells have a high growth fraction and are more sensitive to chemotherapeutic agents than are cells with a low growth fraction.
Rationale 2: Lymphoma cells have a high growth fraction and are more sensitive to chemotherapeutic agents than are cells with a low growth fraction.
Rationale 3: Breast cancer cells have a low growth fraction and are less sensitive to cell cycle specific chemotherapeutic agents.
Rationale 4: Lung cancer cells have a low growth fraction and are less sensitive to cell cycle specific chemotherapeutic agents.
Rationale 5: Bone marrow cells have a high growth fraction and are more sensitive to chemotherapeutic agents than are cells with a low growth fraction.
Global Rationale: Cell cycle specific drugs are most effective in treating hematologic malignancies and other cancers that have a relatively large proportion of cells proliferating at any given point in time. Examples are leukemia, lymphoma, and bone marrow cancers. Lung cancer and breast cancer have low growth fractions and are less sensitive to cell cycle specific chemotherapeutic agents.
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