Which of the following statements regarding positive selection is correct?
a. All subsets of developing T cells undergo positive selection before export to the peripheral circulation.
b. T-cell receptor editing is linked to the process of positive selection.
c. Positive selection results in the production of T cells bearing T-cell receptors that have the capacity to interact with all allotypes of MHC class I and class II molecules, and not just those of the individual.
d. Positive selection ensures that autoreactive T cells are rendered non-responsive.
e. If there is a genetic defect in AIRE, then T-cell development is arrested as positive selection commences.
B
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