In your pathophysiology class you are studying the rheumatic disorders. What should you learn about polymyalgia rheumatica and its pathophysiology? (Mark all that apply.)
A) There is an association with the genetic marker HLA-DR4
B) Immunoglobulin deposits suggest an autoimmune process
C) Occurs predominately in Asians
D) There is no genetic association known
E) Occurs predominately in Caucasians
Ans: A, B, E
Feedback: The underlying mechanism involved with polymyalgia rheumatica is unknown. This disease occurs predominately in Caucasians and often in first-degree relatives. An association with the genetic marker HLA-DR4 suggests a familial predisposition. Immunoglobulin deposits in the walls of inflamed temporal arteries also suggest an autoimmune process. This makes options C and D incorrect.
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