Which serum study should be periodically monitored for elevation in a patient receiving any of the protease inhibitors for the treatment of human immunodeficiency virus (HIV) infection?
a. Liver enzymes
b. Blood urea nitrogen (BUN) and creatinine
c. Lipase and amylase
d. Serum albumin and total protein
ANS: A
The alanine transaminase (ALT), aspartate transaminase (AST), lactate dehydrogenase (LDH), alkaline phosphatase, amylase, bilirubin, creatine phosphokinase, cholesterol, glucose, and uric acid levels should be obtained before initiating therapy and then on a regular basis. A complete blood count (CBC) and comprehensive metabolic panel usually are sufficient to monitor these parameters.
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