When describing the differences affecting the pharmacokinetics of drugs administered to children, which of the following would the nurse include?
A) Oral drugs are absorbed more quickly in children than adults.
B) Absorption of intramuscularly administered drugs is fairly constant.
C) Topical drugs are absorbed more quickly in young children than adults.
D) Absorption of drugs administered by subcutaneous injection is increased.
C
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Topical absorption of drugs is increased in infants and young children because the stratum corneum is thinner and well hydrated. The absorption of oral drugs is slowed by slower gastric emptying, increased intestinal motility, a proportionately larger small intestine surface area, high gastric pH, and decreased lipase and amylase secretion. The absorption of drugs given intramuscularly or subcutaneously is erratic and may be decreased.
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