A drop to pH 4.0 in the duodenum would primarily stimulate the release of ________________.
A. secretin
B. pepsin
C. cholecystokinin
D. insulin
E. gastrin
Clarify Question
· What is the key concept addressed by the question?
· What type of thinking is required?
Gather Content
· What do you know about a hormone secreted in response to acid? What other information is related to the question?
Choose Answer
· Given what you now know, what information is most likely to produce the correct answer?
Reflect on Process
· Did your problem-solving process lead you to the correct answer? If not, where did the process break down or lead you astray? How can you revise your approach to produce a more desirable result?
A. secretin
Clarify Question
· What is the key concept addressed by the question?
o The question asks about a hormone secreted in response to acid.
· What type of thinking is required?
o You are being asked to apply your knowledge about a hormone secreted in response to acid.
Gather Content
· What do you know about a hormone secreted in response to acid? What other information is related to the question?
o The major enterogastrones include cholecystokinin, secretin, and gastric inhibitory peptide. Chyme with high fat content is the strongest stimulus for CCK and GIP secretions, whereas increasing chyme acidity primarily influences the release of secretin. Pepsin is a digestive enzyme secreted into the stomach. Insulin is a blood hormone made by the pancreas. Gastrin and pepsin are made by the stomach.
Choose Answer
· Given what you now know, what information is most likely to produce the correct answer?
o Chyme is acidic and lowers the pH of the duodenum to 4. This stimulates the release of secretin. Gastrin and pepsin are not made in the duodenum, they are made in the intestine. Insulin is made in the pancreas. Cholecystokinin is released in the duodenum, but in response to high fat content.
Reflect on Process
· Did your problem-solving process lead you to the correct answer? If not, where did the process break down or lead you astray? How can you revise your approach to produce a more desirable result?
o This question asked you to apply your knowledge about a hormone secreted in response to acid. If you got the correct answer, great job! If you got an incorrect answer, where did the process break down? Did you think that insulin, gastrin, or pepsin were released into the duodenum? Did you think that cholecystokinin was released in response to low pH?
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