What are the steps involved in B cell activation?
What will be an ideal response?
B cell activation involves many steps. First, antigen-presenting cells present antigenic determinants to Th cells that have complementary binding sites to the presented antigen. Next, Th cells differentiate into Th2 cells. Then, clonal selection takes place, where only the B cells with BCRs complementary to the antigenic determinants will be recognized. When a BCR on the surface of an unactivated B cell binds its epitope, the BCR-antigen complex is endocytosed, and the B cell then displays the epitope on MHC, behaving as an antigen presenting cell. A complementary Th2 cell binds to the B cell by recognizing its antigenic determinant-MHC II complex and then secretes IL-4, which activates the B cell to proliferate rapidly and produce memory cells and plasma cells.
Bloom's Taxonomy: Comprehension
Section: Antibody Immune Responses
Learning Outcome: 16.25
You might also like to view...
The sequence of membrane proteins of the electron transport chain includes three transport proteins and other electron transport proteins. As the electrons from the electron carrier molecules move through the proteins, work is done. The electron transport chain produces a(n) concentration gradient.
A. NADH B. ATP C. oxygen D. proton E. electron
A central vacuole
a. is found only in plant cells. b. may take up between 50% and 90% of the cell's interior. c. regulates water balance. d. is all of the above.
Which type of neuron lies entirely within the central nervous system?
A. motor neuron B. sensory neuron C. interneuron
The process of fixing a slide attaches the microorganisms while simultaneously
a) illuminating the organisms. b) staining the organisms. c) killing the organisms. d) magnifying the organisms.