The nurse is caring for a patient with hepatitis B. The patient is taking adefovir (Hepsera). Which medication would the nurse question if it were ordered?
A) Cimetidine (Tagament)
B) Diltiazem (Cardizem)
C) Diphenhydramine (Benadryl)
D) Telbivudine (Tyzeka)
D
Feedback:
Telbivudine is an anti–hepatitis B agent, and when given with adefovir (Hepsera) can result in severe hepatomegaly with steatosis, sometimes fatal. Cimetidine is a histamine-2 antagonist, diltiazem is a calcium channel blocker, and diphenhydramine is a first-generation antihistamine. These drugs are normally not considered nephrotoxic and could be used with adefovir.
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