Daptomycin requires free calcium for its antibacterial action, is inhibited by pulmonary surfactant, and has activity against gram-positive bacteria. Gram-positive bacterial isolates can be tested for daptomycin susceptibility. For which type of infection should daptomycin susceptibility NOT be reported?
a. Bacteremia
b. Meningitis
c. Pneumonia
d. Skin/Soft tissue infection
C
Daptomycin works best on gram-positive organisms and is often used to treat serious infections caused by methicillin-resistant Staphylococcus spp. However, due to its inactivation by surfactant it is not effective in treating pneumonia and should NOT be reported for patients' isolates causing pneumonia.
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