Why are the red cells larger than normal in megaloblastic anemia?
a. Increased concentration of erythropoietin
b. Increased release of reticulocytes
c. Cells are made larger because fewer of them exist
d. Cell division is impaired
ANS: D
Red cell production is asynchronous in megaloblastic anemias, with nuclear development lagging behind that of the cytoplasm. Because DNA synthesis is affected, cell division does not occur normally and the cells become larger.
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