Serum protein electrophoresis on an elderly patient reveals a monoclonal protein spike. Increased plasma cells are present in the bone marrow
They are CD19 and CD20 negative but demonstrate high-density CD38 and monoclonal cytoplasmic immunoglobulin. What is the most likely diagnosis?
a. Plasma cell myeloma
b. Hodgkin lymphoma
c. Burkitt lymphoma
d. Chronic lymphocytic leukemia
ANS: A
Increased bone marrow plasma cells that are CD19 and CD20 negative but have high density CD38 and monoclonal cytoplasmic immunoglobulin are characteristic of plasma cell myeloma. A monoclonal protein spike is present when serum electrophoresis is performed.
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