For each of the descriptions in questions 1-4, select the B cell signaling molecule (A-I) that most closely matches it
A. Ig?
B. Ig?
C. C3b
D. C3d
E. CR2
F. CD19
G. CD81
H. Fyn
I. Syk
A protein tyrosine kinase homologous to Zap-70, which phosphorylates several adaptor proteins and enzymes
ANS: I. The tyrosine kinase Syk binds through its SH2 domains to the phosphotyrosine residues on the cytoplasmic tails of Igα and Igβ. On activation, Syk, in turn, activates numerous downstream signaling molecules, including B cell linker protein (BLNK). BLNK serves as a scaffolding protein for the activation of different pathways, including the Ras-MAP kinase pathway, the phospholipase C pathway with calcium release, and Btk activation. Ultimately, the same transcription factors that are important players in T cell activation also mediate B cell activation, including NFAT, AP-1, and NF-κB.
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