What components of the erythrocyte membrane are responsible for its negative charge and are also blood group antigens?
a. Peripheral proteins
b. Cholesterol
c. Cation pumps
d. Integral proteins
ANS: D
Integral proteins include the glycophorins, which give the red cell its overall negative charge and are also responsible for the blood group antigens including those of the ABO and Rh systems. The peripheral proteins form the skeletal network of the red cell membrane.
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