In a PET scan, a patient is injected with radioactively labeled glucose. Cells take up the radioactive glucose and the scanner detects levels of radioactivity in various parts of the body. This is a measure of the amount of glucose uptake. Cancer cells are often in an environment with low oxygen concentration and they take in high amounts of glucose. Why would a low oxygen environment lead to high glucose uptake?
A. They rely more on glycolysis which is less efficient than oxidative phosphorylation.
B. Enzymes function more efficiently in the absence of oxygen.
C. They rely more on oxidative phosphorylation which is less efficient than glycolysis.
D. Because they require more oxygen to metabolize glucose.
E. More energy is produced from glucose in hypoxic conditions.
Answer: A
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