What is the mechanism for ACI?
a. Acute phase reactants impair iron mobilization.
b. Inflammation and infections slow heme development.
c. Cytokines prevent iron incorporation into protoporphyrin.
d. Bone marrow iron stores are depleted by acute phase reactants.
ANS: A
The acute phase reactants hepcidin, lactoferrin, and ferritin all contribute to impairing the mobilization of iron for erythropoiesis. Bone marrow iron stores are actually normal to increased in ACI.
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