A client is prescribed acetazolamide (Diamox) to treat absence seizures. Which finding indicates that the next dose of this drug should be withheld?

1. Elevated serum pH
2. Decreased serum potassium
3. Increased seizure frequency
4. Nausea and dizziness


Correct Answer: 2
Rationale 1: A serious adverse effect of acetazolamide (Diamox) is metabolic alkalosis, not metabolic acidosis.
Rationale 2: Hypokalemia is a serious adverse effect of acetazolamide (Diamox).
Rationale 3: Increased seizure frequency would represent a decreased therapeutic effect of the drug for this client.
Rationale 4: Nausea and dizziness can occur as adverse effects of acetazolamide (Diamox) but are not indications to discontinue therapy.
Global Rationale: Hypokalemia is a serious adverse effect of acetazolamide (Diamox). A serious adverse effect of acetazolamide (Diamox) is metabolic alkalosis, not metabolic acidosis. Increased seizure frequency would represent a decreased therapeutic effect of the drug for this client. Nausea and dizziness can occur as adverse effects of acetazolamide (Diamox) but are not indications to discontinue therapy.

Nursing

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