The translocation seen in the Philadelphia chromosome in myelogenous leukemia represents ____
a. a chromosomal aberration that is secondary to the cancer
b. a chromosomal aberration that is caused by the development of cancer
c. a proto-oncogene that has been deleted from chromosome 6 and inserted into chromosome 7
d. a specific chromosomal aberration accompanying a specific cancer
e. the evidence of exposure to chemical carcinogens
d
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Which of the following is not true of small insertions and deletions?
A. They are collectively called indels. B. They can result in the formation of fusion genes. C. They are caused by aberrant recombination or by template slippage during replication. D. They do not cause frameshifts in the amino acid sequence if occurring in multiples of three. E. If only one or two bases are involved, a frameshift will occur in the amino acid sequence.
Gamete formation is
a. the result of mitosis. b. the pairing of homologous chromosomes. c. the formation of sex cells. d. the fusion of gametes. e. a process that occurs only in asexually reproducing forms.
Of the following human trisomies, the one that generally has the most severe impact on the health of the individual is
A) trisomy 21. B) Klinefelter syndrome (XXY). C) trisomy X. D) XYY. E) All of the above have equal impact
In transcriptional interference, how may transcription of a noncoding RNA suppress transcription of a downstream target?
What will be an ideal response?