A patient who is diagnosed with peptic ulcer disease has been started on a regimen that includes ranitidine (Zantac) 300 mg daily at bedtime
The patient calls the clinic 1 week later to report no relief from discomfort. What action will the nurse take?
a. Contact the provider to discuss changing to cimetidine (Tagamet).
b. Notify the provider to discuss increasing the dose.
c. Reassure the patient that the drug may take 1 to 2 weeks to be effective.
d. Suggest that the patient split the medication into twice daily dosing.
ANS: C
Patients taking histamine2 blockers can expect abdominal pain to decrease after 1 to 2 weeks of drug therapy. Cimetidine is not as potent as ranitidine and interacts with many medications through the cytochrome P450 system. Three hundred milligrams is the maximum dose.
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