The histone octamer forms a tightly packed particle, but the N-termini that protrude from the octamer are less ordered. Which is the best explanation for this observation?

A. The charges on the amino acid residues in the N-terminal tails are primarily acidic and repel each other.
B. The charges on the amino acid residues in the N-terminal tails are primarily basic and flex to accommodate the DNA.
C. The N-terminal tails must be flexible because they bind to and then release DNA during transcription.
D. The N-terminal tails must be more flexible because they form intermolecular contacts with other nucleosomes.
E. The N-terminal tails must be more flexible because they interact within the minor groove of DNA.


D

Biology & Microbiology

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