An aide asks the nurse why people who have neurofibromatosis will show varying degrees of the disease. Which genetic principle should the nurse explain to the aide?
a. Penetrance
b. Expressivity
c. Dominance
d. Recessiveness
ANS: B
Expressivity is the extent of variation in phenotype associated with a particular genotype. For neurofibromatosis, a variety of manifestations occur among individuals. The penetrance of a trait is the percentage of individuals with a specific genotype who also exhibit the expected pheno-type. Dominance refers to observable traits and risk of transmission. Recessiveness refers to silent strains with reduced risk of occurrence.
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