The physician has ordered combination therapy for the client with peptic ulcer disease (PUD) who tested positive for H. pylori. The nurse plans to do medication education. What will the best plan by the nurse include?
1. Combination therapy has the best outcomes when antibiotics are used with antacids.
2. Combination therapy has the best outcomes when antibiotics are used with proton-pump inhibitors.
3. The use of sucralfate (Carafate) along with antibiotics is the best combination therapy for peptic ulcer disease (PUD).
4. Various antibiotics are used to eradicate the bacteria that are responsible for the development of peptic ulcer disease (PUD).
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Rationale 1: Combination therapy has the best outcomes when antibiotics are used with proton-pump inhibitors, not with antacids.
Rationale 2: Combination therapy has the best outcomes when antibiotics are used with proton-pump inhibitors.
Rationale 3: Combination therapy has the best outcomes when antibiotics are used with proton-pump inhibitors, not with sucralfate (Carafate).
Rationale 4: More than one antibiotic may be used but is more effective when these antibiotics are used with a proton-pump inhibitor.
Global Rationale: Combination therapy has the best outcomes when antibiotics are used with proton-pump inhibitors when the patient is infected with H. pylori. The best plan does not combine antibiotics with antacids or sucralfate. More than one antibiotic may be used but is more effective when these antibiotics are used with a proton-pump inhibitor.
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