A client's hormone replacement therapy for a health problem has been discontinued. The nurse should instruct the client about which effects because the therapy has been stopped?
Standard Text: Select all that apply.
1. Body cells will need time to adjust to the new hormone level.
2. Target cells are desensitized and are less responsive to the effects of the hormone.
3. Body cells will create more receptors on the plasma membrane to capture hormone molecules.
4. Body cells will send signals that hormone action is needed.
5. Body cells will secrete more hormone.
Correct Answer: 1,2
Rationale 1: When therapy is discontinued, the cells will need time to synthesize more protein receptors and adjust to the new hormone level.
Rationale 2: When a hormone is provided for long periods, the body recognizes an abundance of the hormone and cells will down-regulate the number of receptors for that hormone. This causes a desensitization of the target cells, and they are less responsive to the effects of the hormone.
Rationale 3: This does not occur when hormone replacement therapy is stopped.
Rationale 4: This does not occur when hormone replacement therapy is stopped.
Rationale 5: This does not occur when hormone replacement therapy is stopped.
Global Rationale: When a hormone is provided for long periods, the body recognizes an abundance of the hormone and cells will down-regulate the number of receptors for that hormone. This causes a desensitization of the target cells, and they are less responsive to the effects of the hormone. The cells will need time to synthesize more protein receptors and adjust to the new hormone level. The remaining responses do not occur when hormone therapy is discontinued.
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