Huntington's disease, an often fatal disease of the central nervous system, is inherited from a dominant allele. Furthermore, a person may not show symptoms of the disease until 30 – 50 years of age. Jack and Jill have been married for 40 years and have two children, Joe and Jane. Jack has recently been diagnosed with Huntington's disease. Assuming that Jane does not have the disease, determine
the probability that one of the children will eventually have Huntington's. What is the probability that both Joe and Jane will inherit the disease? Text section: LO2 Key Concept: dominant inheritance Level: Application of concepts
What will be an ideal response?
The probability that one of the children will inherit Huntington's is 1/2. The probability that both will inherit Huntington's is 1/4. Jack is heterozygous and Jill is homozygous, therefore both Joe and Jane have a 50% chance of inheriting Huntington's. To determine the probability that both will inherit Huntington's you must multiply the probabilities of each independent event. Therefore, 1/2 x 1/2 = 1/4.
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