Absorption of medications administered intramuscularly in neonates and infants is best described as:
a. much more rapid than by any other age group
b. more predictable than in adults
c. not influenced by perfusion to the area there administered
d. slow and unreliable
D
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A Incorrect. Absorption of medications administered intramuscularly in neonates and infants is not best described as much more rapid than by any other age group, but slower and unreliable.
B Incorrect. Absorption of medications administered intramuscularly in neonates and infants is not best described as more predictable than in adults, in fact slower and less predictable.
C Incorrect. Absorption of medications administered intramuscularly in neonates and infants is not best described as not influenced by perfusion to the area there administered, but is definitely influenced by reduced perfusion.
D Correct. Absorption of medications administered intramuscularly in neonates and infants is affected by muscle mass and perfusion of the area. Neonates and infants have less muscle mass than older children or adults (25% of body weight compared to 40% of body weight in adults). The smaller muscle size results in less volume capacity and less absorptive surface. There is decreased muscle tone and lower muscle oxygenation and vasomotor instability with diminished and unpredictable peripheral blood flow. Thus, absorption of drugs administered intramuscularly in neonates and infants is best described as slower and unreliable.
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