Antibiotics classified as bacteriocidal protein synthesis inhibitors at normal doses include:
1. gentamicin (Garamycin).
2. tetracycline (Sumycin).
3. clindamycin (Cleocin).
4. erythromycin (E-mycin).
Correct Answer: 1
Rationale 1: Aminoglycosides such as gentamicin have a bacteriocidal effect; that is, they kill the bacteria.
Rationale 2: Tetracycline has a bacteriostatic effect, slowing the growth of the bacteria.
Rationale 3: Clindamycin, a miscellaneous bacterial, has a bacteriostatic effect, slowing the growth of the bacteria.
Rationale 4: Macrolides such as erythromycin have a bacteriostatic effect, slowing the growth of the bacteria.
Global Rationale: Aminoglycosides such as gentamicin have a bacteriocidal effect; that is, they kill the bacteria.
Tetracycline is usually considered bacteriostatic, although it can be bacteriocidal at high concentrations. Clindamycin acts on the 50S bacterial ribosomal subunit in a manner similar to that of the macrolides. It is usually bacteriostatic. Macrolides such as erythromycin are considered bacteriostatic but may be bacteriocidal in high doses.
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