What is true about the genetic transmission of sickle cell disease?
a. Both parents must carry the sickle cell trait.
b. Both parents must have sickle cell disease.
c. One parent must have the sickle cell trait.
d. Sickle cell disease has no known pattern of inheritance.
A
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A In this scenario, there is a 50% risk of having a child with sickle cell disease.
B The sickle cell trait, not the disease itself, must be present in the parents for the
child to have the disease.
C An autosomal recessive pattern of inheritance means that both parents must be
carriers of the sickle cell trait.
D Sickle cell disease is known to have an autosomal recessive pattern of
inheritance.
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