How does tissue inflammation affect local anesthetic drug efficacy?
What will be an ideal response?
When tissues are inflamed at the deposition sites, the lowered pH suppresses the production of base molecules. This suppression may result in insufficient numbers of base molecules (RN) penetrating nerve membranes. Profound anesthesia may become difficult to achieve or, if initially achieved, to sustain. In addition to the increase in hydrogen ions due to the inflammatory response, localized edema and increased circulation may also contribute to failure of profound anesthesia in this situation by decreasing drug concentrations at the delivery site.
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