Predict the results of the following tests in: HS, HE, HPP, PNH, and OHS
a. Ham and sucrose lysis tests
b. Osmotic fragility
c. Immunophenotyping
d. Intracellular ion concentration
What will be an ideal response?
Answer: Ham and sucrose lysis tests: PNH: increased lysis; HS, HE, HPP, and OHS: normal lysis
Osmotic fragility: HS, HPP, and OHS: increased osmotic fragility; HE, and PNH: normal osmotic fragility
Immunophenotyping: PNH: CD55 and CD59: low intensity staining; HS, HE, HPP, and OHS: normal immunophenotyping
Intracellular ion concentration: OHS: increased intracellular sodium; HS, HE, HPP, and PNH: normal intracellular ion concentration
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